Shh Signaling through the Primary Cilium Modulates Rat Oligodendrocyte Differentiation
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Shh Signaling through the Primary Cilium Modulates Rat Oligodendrocyte Differentiation
Primary Cilia (PC) are a very likely place for signal integration where multiple signaling pathways converge. Two major signaling pathways clearly shown to signal through the PC, Sonic Hedgehog (Shh) and PDGF-Rα, are particularly important for the proliferation and differentiation of oligodendrocytes, suggesting that their interaction occurs in or around this organelle. We identified PC in rat ...
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Linda Schneider,1 Christian A. Clement,1 Stefan C. Teilmann,2 Gregory J. Pazour,3 Else K. Hoffmann,1 Peter Satir,4 and Søren T. Christensen1,* 1Department of Biochemistry Institute for Molecular Biology and Physiology University of Copenhagen The August Krogh Building Universitetsparken 13 DK-2100 Copenhagen Ø Denmark 2Laboratory of Reproductive Biology Rigshospitalet DK-2100 Copenhagen Ø Denma...
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www.sciencemag.org (this information is current as of July 23, 2007 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/317/5836/372 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/317/5836/372/DC1 can be found a...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0133567